Pregnenolone is often referred to as the “mother hormone” since it is the first hormone at the top of the cascade that makes progesterone, cortisol, DHEA, testosterone and all estrogens. It’s role in the adrenal-cortisol pathway includes supporting a wide range of anti-inflammatory functions including memory, cognition, immune function, joints and energy.*
Pregnenolone belongs to a group of neurosteroids (like DHEA, DHEA-S, and progesterone) that are in high concentrations in certain areas of the brain. These protect the nerve cells and enhance myelination. Pregnenolone is lipophilic and crosses the blood-brain barrier to support memory and cognition.*
In clinical practice, when serum pregnenolone levels are in the lowest quartile before 8 AM, consideration should be given to full adrenal support which includes:
reducing physical and mental stressors,
supplementation with pregnenolone 50-100 mg,
optimizing all hormones including thyroid,
assessing nutrient status and
detoxifying with 100 ounces of mineralized water
I have found pregnenolone to be a life-saver for patients who have low serum levels and adrenal dysfunction. Once the adrenal function is recovered, patients can reduce and discontinue supplementation.*
This is a fully vegan formula.*
Standard Dosage is 50 mg in AM and/or PM depending on individual effects and as directed by your healthcare provider.
Marx CE, Bradford DW, Hamer RM, et al. Pregnenolone as a novel therapeutic candidate in schizophrenia: emerging preclinical and clinical evidence. Neuroscience. 2011 Sep;191:78–90.
Vallée M, Mayo W, Le Moal M. Role of pregnenolone, dehydroepiandrosterone and their sulfate esters on learning and memory in cognitive aging. Brain Research. Brain Research Reviews. 20001 Nov;37(1-3):301–12.
Dávola ME, Mazaira GI, Galigniana MD, Alché LE, Ramírez JA, Barquero AA. Synthetic pregnenolone derivatives as antiviral agents against acyclovir-resistant isolates of Herpes Simplex Virus Type 1. Antiviral Res. 2015 Oct;122:55-63.
Petit GH, et al. Pregnenolone sulfate and its enantiomer: differential modulation of memory in a spatial discrimination task using forebrain NMDA receptor deficient mice. Neuropsychopharmacology. 2009 Jul;34(8):1885–1903.
Fung LK, et a. Brief Report: An Open-Label Study of the Neurosteroid Pregnenolone in Adults with Autism Spectrum Disorder. J Autism Dev Disord. 2014 Nov; 44(11):2971–2977.