Free Shipping On Retail Orders $50+ / Free Shipping On Wholesale Orders $250+


Liver MD™



  • Liver MD™ is one of our most comprehensive formulas because it covers broad-spectrum liver support. It is comprised of all non-GMO ingredients. Specifically, Liver MD™ promotes:

    • Phase I liver detoxification (detoxication)*

    • Phase II liver detoxication*

    • Antioxidant protection*

    • Glutathione production*

    • Healthy Fat metabolism*

    The liver uses an enzyme-based processing and transport system to eliminate toxins and their intermediates. This enzyme-based system primarily involves Phase I & II Conjugation Liver Detoxification (Detoxication). Phase I and II “conjugates” or attaches molecules to the toxins to better control, process and eliminate them. Initially conjugating a toxin can actually temporarily increase its toxicity, therefore antioxidants and toxin neutralizers are integral to this system. For example, Milk Thistle (Silybum marianum) and N-Acetyl Cysteine (NAC) are two superior neutralizers of many liver toxins passing through Phase I & II processing.

    DIM® is a registered trademark of and is licensed from, BioResponse, LLC, Boulder CO US Patent # 6,086,915

  • Download Liver MD Product Info Sheet

    References

    1. Aguilera-Mendez A, Fernandez-Mejia C. The Hypotriglyceridemic Effect of Biotin Supplementation Involves Increased Levels of cGMP and AMPK Activation. Biofactors. 2012 Sep-Oct;38(5):387-94.
    2. Schenkel LC, et al. Choline Supplementation Restores Substrate Balance and Alleviates Complications of Pcyt2 Deficiency. J Nutr Biochem. 2015 Nov;26(11):1221-34.
    3. Zempleni J, Wijeratne SSK, Hassan YI. Biotin. Biofactors. 2009 Jan-Feb;35(1):36-46.
    4. Banerjee S, et al. Attenuation of Multi-targeted Proliferation-linked Signaling by 3,3’-diindolylmethane (DIM): From Bench to Clinic. Metat Res. 2011 Jul-Oct;728(1-2):47-66.
    5. Le HT, et al. Plant-derived 3,3’-Diindolylmethane.... J Biol Chem. 2003 Jun 6;278(23):21136-45.
    6. Smith S, et al. 3,3’-Diindolylymethane and Genistein.... J Nutri. 2008 Dec;138(12):2379-85.
    7. Yan X, et al. Inhibition of Histone Acetylation by Curcumin.... J Biomed Sci. 2017 Jan 5;24(1):1.
    8. Kalea AZ, Drosatos K, Buxton JL. Nutriepigenetics.... Curr Opin Clin Nutri Metab Care. 2018 Jul;21(4):252-9.
    9. Valdecantos MP, et al. Lipoic acid.... Obesity (Silver Spring). 2012 Oct;20(10):1974-83.
    10. Beaver LM, et al. Toxicol Appl Pharmacol. 2012 Sep 15;263(3):345-51.
    11. Van der Sluis R, et al. New Insights into the Catalytic Mechanism of Human Glycine N-Acyltransferase. J Biochem Mol Toxicol. 2017 Nov;31(11).
    12. Badenhorst CP, van der Sluis R, Erasmus E, van Dijk AA. Glycine conjugation: importance in metabolism, the role of glycine N-acyltransferase, and factors that influence interindividual variation.
    13. Expert Opin Drug Metab Toxicol. 2013 Sep; 9(9):1139-53.
    14. Lin S, et al. Redox-Based Reagents for Chemoselective Methionine Bioconjugation. Science. 2017 Feb 10;355(6325):597-602.
    15. Oredipe OA, Barth RF, Dwivedi C, Webb TE. Dietary Glucarate.... Toxicology. 1992 Sep;74(2-3):209-22.
    16. Dean B, et al. Glucuronidation, Oxidative Metabolism, and Bioactivation of Enterolactone in Rhesus Monkeys. Arch Biochem Biophys 2004 Sep 15;429(2):244-51.
    17. Pantuck EJ, et al. Effect of Brussels Sprouts and Cabbage on Drug Conjugation. Clin Pharmacol Ther. 1084 Feb;35(2):161-9.
    18. Bijak M. Silybin, a Major Bioactive Component of Milk Thistle (Silybum marianum L. Gaent.)-Chemistry, Bioavailability, and Metabolism. Molecules. 2017 Nov 10;22(11): pii: E1942.
    19. Wnag Y, Wang L, Zhu X, Wang D, Li X. Choleretic Activity of Turmeric and its Active Ingredients. J Food Sci. 2016 Jul;81(7):H1800-6.
    20. Hawkins WB, Hanson PC. Bile Salt Metabolism as Influenced by Pure Amino Acids and Casein Digests. J Exp Med. 1949;90(5):461-73.
    21. Gozeneli O, et al. Effects of Thymoquinone and Curcumin on the Regeneration of Rat Livers Subject to 70% Hepatectomy. Acta Cir Bras. 2018 Feb;33(2):110-6.
    22. Abenavoli L, Capasso R, Milic N, Capasso F. Milk Thistle.... Phytother Res. 2010 Oct;24(10):1423-32.
    23. Pascale RM, Feo CF, Calvisi DF, Feo F. Deregulation of Methionine Metabolism.... Transl Gastroenterol Hepatol. 2018 Jun 29;3:36.
    24. Ruan T, Li L, Lyu Y, Luo Q, Wu B. Effect of Methionine Deficiency on Oxidative Stress and Apoptosis in the Small Intestines of Broilers. Acta Vet Hung. 2018 Mar;66(1):52-65.
    25. Milkiewicz P, Roma MG, Cardenas R, Mills CO, Elias E, Coleman R. Effect of tauroursodeoxycholate and S-adenosyl-L-methionine on 17beta-estradiol glucuronide-induced cholestasis. J Hepatol. 2001 Feb;34(2):184-91.
    26. Monti L, et al. N-Acetylcysteine.... Hum Mol Genet. 2015 Oct 1;24(19):5570-80.