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Melatonin 3mg



  • Highest Quality Melatonin

    A dietary supplement that promotes resilient homeostasis, deep restful sleep, provides pivotal support for core immune functions and balance, stimulates vital internal cell production of glutathione, and provides for enhanced repair after assorted types of radiation exposure.*

    The level of melatonin produced by the body is heavily influenced by sunlight, sleep and artificial light. At night, the secretion of melatonin is much higher than during the day. When this process is interrupted, certain symptoms can occur such as: (a) disruptions in the sleep/wake cycle, (b) headaches, (c) mental and physical fatigue and (d) irritability. 


     Melatonin is known to promote healthy defensive responses within our “first tier innate” immunity system.11 From this starting point, melatonin accomplishes beneficial immunomodulation effects directed into our “second tier acquired” immunity system.12 Melatonin also plays many other beneficial roles in immunity, especially in balancing the all-important immune cell inflammatory response.13,14 Melatonin may re-awaken and support healthy white blood cell functions in overweight nursing women.15

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  • REFERENCES

    1. Exp Gerontol. 1998 Nov-Dec;33(7-8):759-72.
    2. Age-related changes in melatonin levels in humans and its potential consequences for sleep disorders.
    3. Waldhauser F, Kovács J, Reiter E.
    4. Karasek, M, Melatonin, human aging, and age-related diseases. Exp Gerontol. 2004 Nov-Dec;39(11-12):1723-9.
    5. Zetner D, Andersen LP, Rosenberg J. Melatonin as Protection Against Radiation Injury: A Systematic Review. Drug Res (Stuttg). 2016 Jun;66(6):281-96. doi: 10.1055/s-0035-1569358. Epub 2016 Jan 20.
    6. Russel J.ReiterAhmetKorkmazShuranMaSergioRosales-CorralDun-XianTan, Melatonin protection from chronic, low-level ionizing radiation, Mutation Research/Reviews in Mutation Research, Volume 751, Issue 1, July–September 2012, Pages 7-14
    7. Eugene AR, Masiak J. The Neuroprotective Aspects of Sleep. MEDtube science. 2015;3(1):35-40.
    8. Bellesi M, Bushey D, Chini M, Tononi G, Cirelli C. Contribution of sleep to the repair of neuronal DNA double-strand breaks: evidence from flies and mice. Scientific Reports. 2016;6:36804. doi:10.1038/srep36804.
    9. Parveen Bhatti, Dana K Mirick, Timothy W Randolph, Jicheng Gong, Diana Taibi Buchanan, Junfeng (Jim) Zhang, Scott Davis. Oxidative DNA damage during night shift work. Occupational and Environmental Medicine, 2017; oemed-2017-104414 DOI: 10.1136/oemed-2017-104414
    10. Carrillo-Vico A, Lardone PJ, Álvarez-Sánchez N, Rodríguez-Rodríguez A, Guerrero JM. Melatonin: Buffering the Immune System. International Journal of Molecular Sciences. 2013;14(4):8638-8683. doi:10.3390/ijms14048638.
    11. Calvo JR, González-Yanes C, Maldonado MD. The role of melatonin in the cells of the innate immunity: a review. J Pineal Res. 2013 Sep;55(2):103-20. doi: 10.1111/jpi.12075. Epub 2013 Jul 24. Review.
    12. Shaji AV, Kulkarni SK, Agrewala JN. Regulation of secretion of IL-4 and IgG1 isotype by melatoninstimulated ovalbumin-specific T cells. Clin Exp Immunol. 1998 Jan;111(1):181-5.
    13. Carrillo-Vico A, Lardone PJ, Álvarez-Sánchez N, Rodríguez-Rodríguez A, Guerrero JM. Melatonin: Buffering the Immune System. International Journal of Molecular Sciences. 2013;14(4):8638-8683. doi:10.3390/ijms14048638.
    14. Carrillo-Vico A, Guerrero JM, Lardone PJ, Reiter RJ. A review of the multiple actions of melatonin on the immune system. Endocrine. 2005 Jul;27(2):189-200. Review.
    15. Morais TC, Honorio-França AC, Fujimori M, et al. Melatonin Action on the Activity of Phagocytes from the Colostrum of Obese Women. Medicina (Kaunas). 2019;55(10):625. Published 2019 Sep 23. doi:10.3390/medicina55100625