Daily Two Multivitamin 60 vcaps

Complete Daily Multivitamin

A two capsule multivitamin with the same hormonal activators as Essentials 5in1 such as Zinc, Selenium, Iodine and B12.  Ideal for sensitive individuals of those who have already achieved optimum nutritional status.

Retail customers: Buy 3 or more at a discounted price.

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A complete daily multivitamin with full doses of nutrients!  This formula incorporates the latest scientific research on nutrition and metabolic functions.  Individual nutrients are formulated for maximum bioavailability, synergy, hormonal activation and anioxidant capacity.  Specific features include:

  • Vitamin A forms which include a complete spectrum of beta-carotene and mixed carotenoids. It is a completely natural form derived from the pristine seas of the South Pacific.
  • Activated B-vitamins with each B vitamin for immediate and sustained release activity. Doses used eliminate the need for stress-B-complex.
  • Vitamin C which is in a very gentle form for the gastrointestinal system.  It is also combined with a full spectrum natural citrus bioflavanoids for maximum absorption.
  • Vitamin E forms known to be synergistically active such as alpha-tocopherol, gamma tocopherol and sesame lignans. Gamma tocopherol is a more effective trap than alpha tocopherol for reactive nitrogen oxides, which are toxic to the body. Alpha tocopherol alone could be deactivated by free radicals without the presence of Gamma Tocopherol.
  • Vitamin K2, which is critical for bone building and its plaque breaking ability. Daily Two and our other multinutrient formula Essentials 5in1 are the only multivitamin formulas currently available that contain Vitamin K2.
  • Albion’s TRAACS® Chelated Minerals: The only clinically proven, chemically validated mineral amino acid chelates. They represent the gold standard in patented, pharmaceutical grade mineral chelates. Every TRAACS® mineral compound is validated and “fingerprinted” to ensure lot-to-lot conformity to Albion’s high standards. TRAACS® mineral amino acid chelates deliver the following measurable results: 1. Highly bioavailable and easily digested 2. Safe, predictable and effective 3. Stable in acidic environments 4. Hypoallergenic, Kosher-Pareve and vegetarian friendly.
  • Digestive Enzyme Blend acts as a crucial cofactor in the proper  absorption of nutrients.
  • Bioperine® has been added because it has been clinically shown to further increase the bioavailability of a wide range of nutrients.

Standard Dosage: Take two capsules daily in divided doses with meals.

These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure or prevent any disease.

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Daily Two Multivitamin   60 vcaps

Daily Two Multivitamin 60 vcaps

Complete Daily Multivitamin

A two capsule multivitamin with the same hormonal activators as Essentials 5in1 such as Zinc, Selenium, Iodine and B12.  Ideal for sensitive individuals of those who have already achieved optimum nutritional status.

Retail customers: Buy 3 or more at a discounted price.

Write your review

  1. Vitamins for Chronic Disease Prevention in Adults  JAMA. 2002;287:3127-3129.
  2. Holick MF. High prevalence of vitamin D inadequacy and implications for health. Mayo Clin Proc. 2006 Mar;81(3):353-73.
  3. Maras JE, Bermudez OI, Qiao N, et al. Intake of alpha-tocopherol is limited among US adults. J Am Diet Assoc. 2004; 104 :567 –75.
  4. Wright ME, Lawson KA, Weinstein SJ, Pietinen P, Taylor PR, Virtamo J, Albanes D. Higher baseline serum concentrations of vitamin E are associated with lower total and cause-specific mortality in the Alpha-Tocopherol, Beta-Carotene Cancer Prevention Study. Am J Clin Nutr. 2006 Nov;84(5):1200-7.
  5. Khatami M, Suldan Z, David I, et al. Inhibitory effects of pyridoxal phosphate, ascorbate and aminoguanidine on nonenzymatic glycosylation. Life Sci. 1988;43(21):1725-31.
  6. Nakamura S, Niwa T. Pyridoxal phosphate and hepatocyte growth factor prevent dialysate-induced peritoneal damage. J Am Soc Nephrol. 2005 Jan;16(1):144-50. Epub 2004 Nov 24.
  7. Doetsch AM, Faber J, Lynnerup N, et al. The effect of calcium and vitamin D-3 supplementation on the healing of the proximal humerus fracture: a randomized placebo controlled study. Calcif Tissue Int. 2004 Sep;75(3): 183-8.
  8. Flood A, Schatzkin A. Colorectal cancer: does it matter if you eat your fruits and vegetables? J Natl Cancer Inst. 2000;92:1706-1707.
  9. Lips P. Vitamin D deficiency and secondary hyperparathyroidism in the elderly. Endocr Rev. 2001;22:477-501.
  10. Oakley GP Jr. Eat right and take a multivitamin. N Engl J Med. 1998;338:1060-1061
  11. Committee on Diet and Health NRC. Diet and Health: Implications for Reducing Chronic Disease Risk. Washington, DC: National Academy Press; 1989
  12. A Role for Multivitamins in Infection Fawzi and Stampfer ANN INTERN MED 2003;138:430-431.
  13. Oxidative damage and defense. Am J Clin Nutr. 1996 Jun;63(6):985S-990S. Jacob RA, Burri BJ.
  14. Effect of vitamin C supplementation on oxidative stress in experimental diabetes. Indian J Exp Biol. 1997 Mar;35(3):264-6. Garg MC, Singh KP, Bansal DD.
  15. Effect of homocysteine-lowering therapy with folic acid, vitamin B12, and vitamin B6 on clinical outcome after percutaneous coronary intervention: the Swiss Heart study: a randomized controlled trial. JAMA. 2002 Aug 28;288(8):973-9. Schnyder G, Roffi M, Flammer Y, Pin R, Hess OM.
  16. Multivitamin/mineral supplementation improves plasma B-vitamin status and homocysteine concentration in healthy older adults consuming a folate-fortified diet. J Nutr. 2000 Dec;130(12):3090-6. McKay DL, Perrone G, Rasmussen H, Dallal G, Blumberg JB.
  17. Plasma homocysteine, a risk factor for cardiovascular disease, is lowered by physiological doses of folic acid. QJM. 1997 Aug;90(8):519-24. Ward M, McNulty H, McPartlin J, Strain JJ, Weir DG, Scott JM.
  18. Inhibition of inflammation and carcinogenesis in the lung and colon by tocopherols. Ann N Y Acad Sci. 2010 Aug;1203:29-34. Yang CS, Lu G, Ju J, Li GX. “Although alpha-tocopherol (alpha-T) is the major form of vitamin E found in the blood and tissues, gamma- and delta-T have been suggested to have stronger anti-inflammatory activities. “
  19. Gamma-tocopherol, the major form of vitamin E in the US diet, deserves more attention. Am J Clin Nutr. 2001 Dec;74(6):714-22. Jiang Q, Christen S, Shigenaga MK, Ames BN. “.. gamma-Tocopherol appears to be a more effective trap for lipophilic electrophiles than is alpha-tocopherol…Both gamma-tocopherol and gamma-CEHC, but not alpha-tocopherol, inhibit cyclooxygenase activity and, thus, possess anti-inflammatory properties.
  20. Carr AC, Frei B. Toward a new recommended dietary allowance for vitamin C based on antioxidant and health effects in humans. Am J Clin Nutr. 1999;69(6):1086-1107. (PubMed)
  21. Simon JA, Hudes ES. Serum ascorbic acid and gallbladder disease prevalence among US adults: the Third National         Health and Nutrition Examination Survey (NHANES III). Arch Intern Med. 2000;160(7):931-936.  (PubMed)
  22. Bruno RS, Leonard SW, Atkinson J, et al. Faster plasma vitamin E disappearance in smokers is normalized by vitamin C supplementation. Free Radic Biol Med. 2006;40(4):689-697.  (PubMed)
  23. Sauberlich, HE. A history of scurvy and vitamin C. In Packer, L. and Fuchs, J, eds. Vitamin C in health and disease. New York: Marcel Decker Inc. 1997: pages 1-24.
  24. Stephen R, Utecht T. Scurvy identified in the emergency department: a case report. J Emerg Med. 2001;21(3):235-237.(PubMed)
  25. Weinstein M, Babyn P, Zlotkin S. An orange a day keeps the doctor away: scurvy in the year 2000. Pediatrics. 2001;108(3):E55.(PubMed)
  26. Food and Nutrition Board, Institute of Medicine. Vitamin C. Dietary Reference Intakes for Vitamin C, Vitamin E, Selenium, and Carotenoids. Washington D.C.: National Academy Press; 2000:95-185.(National Academy Press)
  27. e Z, Song H. Antioxidant vitamins intake and the risk of coronary heart disease: meta-analysis of cohort studies. Eur J Cardiovasc Prev Rehabil. 2008;15(1):26-34.   (PubMed)
  28. Losonczy KG, Harris TB, Havlik RJ. Vitamin E and vitamin C supplement use and risk of all-cause and coronary heart disease mortality in older persons: the Established Populations for Epidemiologic Studies of the Elderly. Am J Clin Nutr. 1996;64(2):190-196.  (PubMed)
  29. Kushi LH, Folsom AR, Prineas RJ, Mink PJ, Wu Y, Bostick RM. Dietary antioxidant vitamins and death from coronary  heart disease in postmenopausal women. N Engl J Med. 1996;334(18):1156-1162.  (PubMed)
  30. Muntwyler J, Hennekens CH, Manson JE, Buring JE, Gaziano JM. Vitamin supplement use in a low-risk population of US male physicians and subsequent cardiovascular mortality. Arch Intern Med. 2002;162(13):1472-1476.  (PubMed)
  31. Enstrom JE, Kanim LE, Klein MA. Vitamin C intake and mortality among a sample of the United States population.  Epidemiology. 1992;3(3):194-202.  (PubMed)
  32. Enstrom JE. Counterpoint--vitamin C and mortality. Nutr Today. 1993;28:28-32.
  33. Osganian SK, Stampfer MJ, Rimm E, et al. Vitamin C and risk of coronary heart disease in women. J Am Coll Cardiol. 2003;42(2):246-252.  (PubMed)
  34. Knekt P, Ritz J, Pereira MA, et al. Antioxidant vitamins and coronary heart disease risk: a pooled analysis of 9 cohorts. Am J Clin Nutr. 2004;80(6):1508-1520.  (PubMed)
  35. Sesso HD, Buring JE, Christen WG, et al. Vitamins E and C in the prevention of cardiovascular disease in men: the Physicians' Health Study II randomized controlled trial. JAMA. 2008;300(18):2123-2133.  (PubMed)
  36. Roberts LJ, 2nd, Traber MG, Frei B. Vitamins E and C in the prevention of cardiovascular disease and cancer in men. Free Radic Biol Med. 2009;46(11):1558.  (PubMed)
  37. Levine M, Wang Y, Padayatty SJ, Morrow J. A new recommended dietary allowance of vitamin C for healthy young women. Proc Natl Acad Sci U S A. 2001;98(17):9842-9846.  (PubMed)
  38. Frei B. To C or not to C, that is the question! J Am Coll Cardiol. 2003;42(2):253-255.
  39. Yokoyama T, Date C, Kokubo Y, Yoshiike N, Matsumura Y, Tanaka H. Serum vitamin C concentration was inversely associated with subsequent 20-year incidence of stroke in a Japanese rural community. The Shibata study. Stroke. 2000;31(10):2287-2294.  (PubMed)
  40. Myint PK, Luben RN, Welch AA, Bingham SA, Wareham NJ, Khaw KT. Plasma vitamin C concentrations predict risk of incident stroke over 10 y in 20 649 participants of the European Prospective Investigation into Cancer Norfolk prospective population study. Am J Clin Nutr. 2008;87(1):64-69.  (PubMed)
  41. Ingraham BA, Bragdon B, Nohe A. Molecular basis of the potential of vitamin D to prevent cancer. Curr Med Res Opin. 2008;24:139-49.
  42. Lappe JM, Travers-Gustafson D, Davies KM, Recker RR, Heaney RP. Vitamin D and calcium supplementation reduces cancer risk: results of a randomized trial. Am J Clin Nutr. 2007 Jun;85(6):1586-91.
  43. Moan J, Porojnicu AC, Dahlback A, Setlow RB. Addressing the health benefits and risks, involving vitamin D or skin cancer, of increased sun exposure. Proc Natl Acad Sci U S A. 2008 Jan 15;105(2):668-73.
  44. Ng K, Meyerhardt JA, Kana Wu, Feskanich D, Hollis BW, Giovannucci EL, Fuchs CS. Circulating 25-hydroxyvitamin D levels and survival in patients with colorectal cancer J Clin Oncol. Jun 20 2008: 2984–2991.
  45. Nürnberg B, Schadendorf D, Gärtner B, Pföhler C, Herrmann W, Tilgen W, Reichrath J. Progression of malignant melanoma is associated with reduced 25-hydroxyvitamin D serum levels. Exp Dermatol. 2008 Jul;17(7):627.
  46. Pilz S, Dobnig H, Winklhofer-Roob B, Riedmüller G, Fischer JE, Seelhorst U, Wellnitz B, Boehm BO, März W. Low serum levels of 25-hydroxyvitamin d predict fatal cancer in patients referred to coronary angiography. Cancer Epidemiol Biomarkers Prev. 2008 May;17(5):1228-33.
  47. Porojnicu AC, Dahlback A, Moan J. Sun exposure and cancer survival in Norway: changes in the risk of death with season of diagnosis and latitude. Adv Exp Med Biol. 2008;624:43-54.
  48. Reichrath J, Nürnberg B. Solar UV-radiation, vitamin D and skin cancer surveillance in organ transplant recipients (OTRs). Adv Exp Med Biol. 2008;624:203-14. Review.
  49. Adams JS, Hewison M. Unexpected actions of vitamin D: new perspectives on the regulation of innate and adaptive immunity. Nat Clin Pract Endocrinol Metab. 2008 Feb;4(2):80-90.
  50. Aloia JF, Li-Ng M. Re: epidemic influenza and vitamin D. Epidemiol Infect. 2007 Oct;135(7):1095-6; author reply 1097-8.
  51. Bikle DD. Vitamin D and the immune system: role in protection against bacterial infection. Curr Opin Nephrol Hypertens. 2008 Jul;17(4):348-52.
  52. Cannell JJ, Vieth R, Umhau JC, Holick MF, Grant WB, Madronich S, Garland CF, Giovannucci E. Epidemic influenza and vitamin D. Epidemiol Infect. 2006 Dec;134(6):1129-40.
  53. Cannell JJ, Zasloff M, Garland CF, Scragg R, Giovannucci E. On the epidemiology of influenza. Virol J. 2008 Feb 25;5:29.
  54. Liu PT, Stenger S, Tang DH, Modlin RL. Cutting edge: vitamin D-mediated human antimicrobial activity against Mycobacterium tuberculosis is dependent on the induction of cathelicidin. J Immunol. 2007 Aug 15;179(4):2060-3.
  55. Mookherjee N, Rehaume LM, Hancock RE. Cathelicidins and functional analogues as antisepsis molecules. Expert Opin Ther Targets. 2007 Aug;11(8):993-1004. Review.
  56. White JH. Vitamin D signaling, infectious diseases, and regulation of innate immunity. Infect Immun. 2008 Sep;76(9):3837-43.
  57. Dobnig H, Pilz S, Scharnagl H, Renner W, Seelhorst U, Wellnitz B, Kinkeldei J, Boehm BO, Weihrauch G, Maerz W. Independent Association of Low Serum 25-Hydroxyvitamin D and 1,25-Dihydroxyvitamin D Levels With All-Cause and Cardiovascular Mortality. Arch Intern Med. 2008;168(12):1340-1349.
  58. Forman JP, Giovannucci E, Holmes MD, Bischoff-Ferrari HA, Tworoger SS, Willett WC, Curhan GC. Plasma 25-hydroxyvitamin D levels and risk of incident hypertension. Hypertension. 2007 May;49(5):1063-9.
  59. Giovannucci E, Liu Y, Hollis BW, Rimm EB. 25-hydroxyvitamin D and risk of myocardial infarction in men: a prospective study. Arch Intern Med. 2008 Jun 9;168(11):1174-80.
  60. Martins D, Wolf M, Pan D, Zadshir A, Tareen N, Thadhani R, Felsenfeld A, Levine B, Mehrotra R, Norris K. Prevalence of cardiovascular risk factors and the serum levels of 25-hydroxyvitamin D in the United States: data from the Third National Health and Nutrition Examination Survey. Arch Intern Med. 2007 Jun 11;167(11):1159-65.
  61. Michos ED, Melamed ML. Vitamin D and cardiovascular disease risk. Curr Opin Clin Nutr Metab Care. 2008 Jan;11(1):7-12.
  62. Melamed ML, Michos ED, Post W, Astor B. 25-hydroxyvitamin d levels and the risk of mortality in the general population. Arch Intern Med. 2008 Aug 11;168(15):1629-37.
  63. Pilz S, Dobnig H, Fischer JE, Wellnitz B, Seelhorst U, Boehm BO, März W. Low Vitamin D Levels Predict Stroke in Patients Referred to Coronary Angiography. Stroke. 2008 Sep;39(9):2611-3.
  64. Pilz S, März W, Wellnitz B, Seelhorst U, Fahrleitner-Pammer A, Dimai HP, Boehm BO, Dobnig H. Association of vitamin D deficiency with heart failure and sudden cardiac death in a large cross-sectional study of patients referred for coronary angiography. J Clin Endocrinol Metab. 2008 Aug 5. [Epub ahead of print]
  65. Wang TJ, Pencina MJ, Booth SL, Jacques PF, Ingelsson E, Lanier K, Benjamin EJ, D'Agostino RB, Wolf M, Vasan RS. Vitamin D deficiency and risk of cardiovascular disease. Circulation. 2008 Jan 29;117(4):503-11.
  66. Knekt P, Laaksonen M, Mattila C, Härkänen T, Marniemi J, Heliövaara M, Rissanen H, Montonen J, Reunanen A. Serum Vitamin D and Subsequent Occurrence of Type 2 Diabetes. Epidemiology. 2008 May 20. [Epub ahead of print]
  67. Pittas AG, Lau J, Hu FB, Dawson-Hughes B. The role of vitamin D and calcium in type 2 diabetes. A systematic review and meta-analysis. J Clin Endocrinol Metab. 2007 Jun;92(6):2017-29.
  68. Albert CM, Cook NR, Gaziano JM, et al. Effect of folic acid and B vitamins on risk of cardiovascular events and total mortality among women at high risk for cardiovascular disease: a randomized trial. JAMA. 2008 May 7;299(17):2027-36.
  69. Andres E, Serraj K, Mecili M, Ciobanu E, Vogel T, Weitten T. Update of oral vitamin B12. Ann Endocrinol (Paris). 2009 Dec;70(6):455-61. Epub 2009 Aug 15.
  70. Bjørke-Monsen AL, Torsvik I, Saetran H, et al. Common metabolic profile in infants indicating impaired cobalamin status responds to cobalamin supplementation. Pediatrics 2008 Jul;122(1):83-91.
  71. Erol I, Alehan F, G;uuml;m;uuml;s A. West syndrome in an infant with vitamin B12 deficiency in the absence of macrocytic anaemia. Dev Med Child Neurol 2007 Oct;49(10):774-6.
  72. Eussen SJ, de Groot LC, Clarke R, et al. Oral cyanocobalamin supplementation in older people with vitamin B12 deficiency: a dose-finding trial. Arch Intern Med 2005 May 23;165(10):1167-72.
  73. Force RW, Meeker AD, Cady PS, et al. Increased vitamin B12 requirement associated with chronic acid suppression therapy. Ann Pharmacother 2003;37:490-3.
  74. Haggarty P, McCallum H, McBain H, Effect of B vitamins and genetics on success of in-vitro fertilisation: prospective cohort study. Lancet 2006 May 6;367(9521):1513-9.
  75. Lehman JS, Bruce AJ, Rogers RS. Atrophic glossitis from vitamin B12 deficiency: a case misdiagnosed as burning mouth disorder. J Periodontol 2006 Dec;77(12):2090-2.
  76. Malouf R, Grimley Evans J. Folic acid with or without vitamin B12 for the prevention and treatment of healthy elderly and demented people. Cochrane Database Syst Rev 2008 Oct 8;(4):CD004514.
  77. Molloy AM, Kirke PN, Brody LC, et al. Effects of folate and vitamin B12 deficiencies during pregnancy on fetal, infant, and child development. Food Nutr Bull 2008 Jun;29(2 Suppl):S101-11; discussion S112-5.
  78. Ryan-Harshman M, Aldoori W. Vitamin B12 and health. Can Fam Physician 2008 Apr;54(4):536-41.
  79. Seal EC, Metz J, Flicker L, et al. A randomized, double-blind, placebo-controlled study of oral vitamin B12 supplementation in older patients with subnormal or borderline serum vitamin B12 concentrations. J Am Geriatr Soc 2002;50:146-51.
  80. Suzuki DM, Alagiakrishnan K, Masaki KH, et al. Patient acceptance of intranasal cobalamin gel for vitamin B12 replacement therapy. Hawaii Med J 2006 Nov;65(11):311-4.
  81. Toole JF, Malinow MR, Chambless LE, et al. Lowering homocysteine in patients with ischemic stroke to prevent recurrent stroke, myocardial infarction, and death: the Vitamin Intervention for Stroke Prevention (VISP) randomized controlled trial. JAMA 2004;291:565-75.
  82. Yajnik CS, Lubree HG, Thuse NV, et al. Oral vitamin B12 supplementation reduces plasma total homocysteine concentration in women in India. Asia Pac J Clin Nutr 2007;16(1):103-9.
  83. . Robinson K, Arheart K, Refsum H, et al. Low circulating folate and vitamin B6 concentrations: risk factors for stroke, peripheral vascular disease, and coronary artery disease. European COMAC Group.Circulation. 1998; 97(5):437–44
  84. Robinson K, Mayer EL, Miller DP, et al. Hyperhomocysteinemia and low pyridoxal phosphate. Common and independent reversible risk factors for coronary artery disease. Circulation. 1995; 92(10):2825–2830.
  85. Lin PT, Cheng CH, Liaw YP, Lee BJ, Lee TW, Huang YC. Low pyridoxal 5'-phosphate is associated with increased risk of coronary artery disease. Nutrition. 2006; 22(11-12):1146–1151
  86. Meydani SN, Ribaya-Mercado JD, Russell RM, Sahyoun N, Morrow FD, Gershoff SN. Vitamin B-6 deficiency impairs interleukin 2 production and lymphocyte proliferation in elderly adults. Am J Clin Nutr. 1991; 53(5):1275–1280.
  87. Talbott MC, Miller LT, Kerkvliet NI. Pyridoxine supplementation: effect on lymphocyte responses in elderly persons. Am J Clin Nutr. 1987; 46(4):659–664
  88. Selhub J, Bagley LC, Miller J, Rosenberg IH. B vitamins, homocysteine, and neurocognitive function in the elderly. Am J Clin Nutr. 2000; 71(2):614S–620S
  89. Deijen JB, van der Beek EJ, Orlebeke JF, van den Berg H. Vitamin B-6 supplementation in elderly men: effects on mood, memory, performance and mental effort. Psychopharmacology (Berl). 1992; 109(4):489–49
  90. Bryan J, Calvaresi E, Hughes D. Short-term folate, vitamin B-12 or vitamin B-6 supplementation slightly affects memory performance but not mood in women of various ages. J Nutr. 2002; 132(6):1345–1356
  91. Balk EM, Raman G, Tatsioni A, Chung M, Lau J, Rosenberg IH. Vitamin B6, B12, and folic acid supplementation and cognitive function: a systematic review of randomized trials. Arch Intern Med. 2007; 167(1):21–30.
  92. Curhan GC, Willett WC, Speizer FE, Stampfer MJ. Intake of vitamins B6 and C and the risk of kidney stones in women. J Am Soc Nephrol. 1999; 10(4):840–845.
  93. Curhan GC, Willett WC, Rimm EB, Stampfer MJ. A prospective study of the intake of vitamins C and B6, and the risk of kidney stones in men. J Urol. 1996; 155(6):1847–1851
  94. Bender DA. Non-nutritional uses of vitamin B6. Br J Nutr. 1999; 81(1):7–20.
  95. Kleijnen J, Ter Riet G, Knipschild P. Vitamin B6 in the treatment of the premenstrual syndrome--a review. Br J Obstet Gynaecol. 1990; 97(9):847–852
  96. Wyatt KM, Dimmock PW, Jones PW, Shaughn O'Brien PM. Efficacy of vitamin B-6 in the treatment of premenstrual syndrome: systematic review. Bmj. 1999; 318(7195):1375–1381
  97. Williams AL, Cotter A, Sabina A, Girard C, Goodman J, Katz DL. The role for vitamin B-6 as treatment for depression: a systematic review. Fam Pract. 2005; 22(5):532–537.